General Information

  • ID:  hor001617
  • Uniprot ID:  P41487
  • Protein name:  FMRFamide-like neuropeptide 4
  • Gene name:  NA
  • Organism:  Homarus americanus (American lobster)
  • Family:  FARP (FMRFamide related peptide) family
  • Source:  animal
  • Expression:  NA
  • Disease:  NA
  • Comments:  NA
  • Taxonomy:  Homarus (genus), Nephropidae (family), Nephropoidea (superfamily), Astacidea (infraorder), Pleocyemata (suborder), Decapoda (order), Eucarida (superorder), Eumalacostraca (subclass), Malacostraca (class), Multicrustacea (superclass), Crustacea (subphylum), Pancrustacea, Mandibulata, Arthropoda (phylum), Panarthropoda, Ecdysozoa, Protostomia, Bilateria, Eumetazoa, Metazoa (kingdom), Opisthokonta, Eukaryota (superkingdom), cellular organisms
  • GO MF:  NA
  • GO BP:  GO:0007218 neuropeptide signaling pathway
  • GO CC:  GO:0005576 extracellular region

Sequence Information

  • Sequence:  TNRNFLRF
  • Length:  8(1-8)
  • Propeptide:  TNRNFLRF
  • Signal peptide:  NA
  • Modification:  T8 Phenylalanine amide
  • Glycosylation:  NA
  • Mutagenesis:  NA

Activity

  • Function:  Can act as a modulator of exoskeletal and cardiac neuromuscular junctions.
  • Mechanism:  NA
  • Cross BBB:  NO
  • Target:  NA
  • Target Unid:  NA
  • IC50: NA
  • EC50: NA
  • ED50: NA
  • kd: NA
  • Half life: NA

Structure

  • Disulfide bond:  NA
  • Structure ID:  NA

  • Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)
    •    hor001617_AF2.pdbhor001617_ESM.pdb

Physical Information

Mass: 119224 Formula: C48H74N16O12
Absent amino acids: ACDEGHIKMPQSVWY Common amino acids: FNR
pI: 12.5 Basic residues: 2
Polar residues: 3 Hydrophobic residues: 3
Hydrophobicity: -91.25 Boman Index: -3481
Half-Life: 7.2 hour Half-Life Yeast: >20 hour
Half-Life E.Coli: >10 hour Aliphatic Index 48.75
Instability Index: 1067.5 Extinction Coefficient cystines: 0
Absorbance 280nm: 0

Literature

  • PubMed ID:  3429714
  • Title:  Purification and Characterization of FMRFamidelike Immunoreactive Substances From the Lobster Nervous System: Isolation and Sequence Analysis of Two Closely Related Peptides